NAD+ Therapy

NAD+ serves as an essential cofactor for hundreds of enzymatic reactions in the body. It is indispensable for mitochondrial function, where it facilitates the electron transport chain that produces cellular ATP energy. NAD+ also activates sirtuins, a family of seven enzymes that regulate cellular stress responses, DNA repair, inflammation, and metabolism. Additionally, it serves as a substrate for PARP enzymes involved in DNA damage repair and for CD38, which modulates immune cell function and calcium signaling. The age-related decline in NAD+ compromises all of these processes simultaneously, which is why its restoration is considered a high-leverage intervention in longevity science.

NAD+ therapy is commonly sought by individuals experiencing age-related fatigue and cognitive decline who want to address these concerns at the cellular level. Patients in recovery from substance overuse frequently seek NAD+ for its potential to support neurological restoration. High-performing executives, athletes, and longevity-focused individuals use NAD+ to maintain peak cellular function and energy production.

NAD+ can be administered through intravenous infusion, intramuscular injection, subcutaneous injection, or oral supplementation with precursors such as NMN or NR. IV infusions provide the highest bioavailability but require several hours due to the need for slow administration to avoid side effects. Subcutaneous and intramuscular injections offer a more practical alternative. Oral precursors are the most convenient but may have lower bioavailability for raising NAD+ levels directly.